Before white settlement this was the land of the Tharawal and Gundungurra peoples. The property later known as Smeaton Grange was originally called Naralling Grange and was a land grant of 283 hectares (700 acres) by Governor Macquarie in 1816 to Captain William Hovell.
Smeaton was also an adjoining land grant to Charles Throsby who was an early settler and town leader in Campbelltown. Both of these landholdings were purchased by James Fitzpatrick who had come to Australia as a convict in 1822 and who worked as a servant of Hamilton Hume. Fitzpatrick accompanied Hume and Hovell on their famous 1824 expedition to Port Phillip Bay. He later became a prosperous farmer. The property first grew wheat, and when rust developed, moved into sheep production and later dairy farming.
During World War Two the house was used as a residence for army officers. The Catholic Church acquired the property in the early 1960s and the Patrician Brothers Order used it as a religious house, retreat centre and novitiate till it was developed as part of Magdalene High School in 2000. In the early 1990s the area of land north of the house was zoned industrial. The new industrial estate has been able to attract a wide range of business both large and small and continues to grow as an industrial centre for the area.